detection of extended spectrum beta lactamase producing salmonella spp. and multidrug resistance pattern

Authors

ali jazayeri moghadas

gholamreza irajian

reza ranjbar

abstract

background: and objectives: salmonella infections are endemic in many developing countries with poor sanitary conditions, but emerge sporadically as a serious public health threat in developed countries. infections with multidrug resistant (mdr) strains of salmonella have been associated with treatment failures. salmonella spp. resistant to extended spectrum cephalosporins are increasing in prevalence worldwide. the aim of this study was to determine the antimicrobial susceptibility, multidrug resistance and extended spectrum beta lactamase (esbl) production among clinical isolates of salmonella spp. during 2007 in tehran, iran. patients and methods: in this cross-sectional study, fifty salmonella spp. were identified by api 20e system and serotyped by the slide agglutination test. disk diffusion test was performed. double disk synergy test was used as a screening test for esbl production, using disks of cefotaxime and ceftazidime with and without clavulanic acid. results: from 50 salmonella spp. 12 (24%) were s. enterica serotype paratyphi b, 24 (48%) s. enterica serotype paratyphi c and 14 (28%) were s. enterica serotype typhi. the most susceptibility and resistance were observed to ceftazidime (98%) and amoxicillin-clavulanic acid (96%), respectively. 28(56%) were resistant to 5 or more antibiotics.  esbl production was detected by double disk synergy test in one isolate (2%).   conclusion: results showed increase in antibiotic and multidrug resistance pattern of salmonella spp. comparing to previous studies in iran and other countries.it seems that this is the first report of salmonella spp. esbl producing in iran.

Upgrade to premium to download articles

Sign up to access the full text

Already have an account?login

similar resources

Detection of Extended Spectrum Beta Lactamase Producing Salmonella spp. and Multidrug Resistance Pattern

  Background: and Objectives: Salmonella infections are endemic in many developing countries with poor sanitary conditions, but emerge sporadically as a serious public health threat in developed countries. Infections with multidrug resistant (MDR) strains of Salmonella have been associated with treatment failures. Salmonella spp. resistant to extended spectrum cephal...

full text

Detection of Extended Spectrum Beta Lactamase Producing Salmonella spp. and Multidrug Resistance Pattern

Background and Objectives: Salmonella infections are endemic in many developing countries with poor sanitary conditions, but emerge sporadically as a serious public health threat in developed countries. Infections with multidrug resistant (MDR) strains of Salmonella have been associated with treatment failures. Salmonella spp. resistant to extended spectrum cephalosporins are increasing in prev...

full text

Evaluation of a chromogenic medium for rapid detection of extended spectrum beta-lactamase producing Salmonella spp.

BACKGROUND & OBJECTIVES Salmonella spp. resistant to second- and third-generation cephalosporins and related antibiotics by production of various extended-spectrum beta-lactamases (ESBLs) are on the rise in Turkey. Early detection of ESBL producing Salmonella is important to institute appropriate treatment in time. In this study rapid detection of ESBL production among clinical isolates of Salm...

full text

Antimicrobial Pattern and Clonal Dissemination of Extended-Spectrum Beta-Lactamase Producing Klebsiella Spp Isolates

Problem statement: Gram-negative pathogens harboring ESBLs have caused numerous outbreaks of infections and are becoming an increasing therapeutic problem in many countries. The incidence of ESBL-producing strains among clinical isolates has been steadily increasing over the past years resulting in limitations of therapeutic option. The focus of this study was to examine the molecular epidemiol...

full text

Integron mediated multidrug resistance in extended spectrum beta-lactamase producing clinical isolates of Klebsiella pneumoniae

The present study describes integron mediated multiple antibiotic resistance in extended-spectrum β-lactamase producing clinical isolates of Klebsiella pneumoniae. One hundred and four clinical isolates of K. pneumoniae from two Iranian hospitals were screened for extended-spectrum β-lactamase production and susceptibility of the extended-spectrum β-lactamase producing isolates was determined t...

full text

Characterization of multidrug-resistant, qnrB2-positive and extended-spectrum-beta-lactamase-producing Salmonella Concord and Salmonella Senftenberg isolates.

OBJECTIVES To characterize plasmids and resistance genes of multidrug-resistant (MDR) Salmonella Senftenberg and Salmonella Concord isolated from patients in the Netherlands. METHODS The resistance genes of four MDR Salmonella isolates (three Salmonella Concord and one Salmonella Senftenberg) were identified by miniaturized microarray, PCR and sequencing. Plasmids were characterized by S1 nuc...

full text

My Resources

Save resource for easier access later


Journal title:
iranian journal of pathology

Publisher: iranian society of pathology

ISSN 1735-5303

volume 4

issue 3 2009

Hosted on Doprax cloud platform doprax.com

copyright © 2015-2023